At present, chiral drugs have occupied an important position in the global drug market. Chiral drugs have the characteristics of high technical threshold, good economic benefits, high curative effect, less toxic and side effects and less dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry.

There are three main ways to prepare chiral drugs:

1: Extracting chiral drugs or their chiral intermediates from natural products;

2: The racemic chiral drugs or their chiral intermediates are separated by resolution methods, including crystal resolution, chemical resolution, kinetic resolution, chromatographic resolution and biological enzyme resolution;

3: Asymmetric reactions are used to synthesize chiral drugs or their chiral intermediates, mainly including chemical synthesis and biosynthesis.